Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005645)
Formula
SVG example
O-demethylation
Reactant Verapamil metabolite D-617 Product Verapamil metabolite PR-25
Reactant Info Product Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010526 Verapamil D-617 Unclear - Unclear Verapamil [1]
MR005644 Verapamil hydrochloride Verapamil metabolite D-617 Oxidation - N-dealkylation Verapamil hydrochloride [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010528 D-617 D-620 Unclear - Unclear Verapamil [1]
MR005646 Verapamil metabolite D-617 Verapamil metabolite D-620 Oxidation - N-dealkylation Verapamil hydrochloride [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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