Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005646)
Formula
CYP3A5 ...
SVG example
N-dealkylation
Reactant Verapamil metabolite D-617 Product Verapamil metabolite D-620
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010526 Verapamil D-617 Unclear - Unclear Verapamil [1]
MR005644 Verapamil hydrochloride Verapamil metabolite D-617 Oxidation - N-dealkylation Verapamil hydrochloride [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010527 D-617 PR 25 Unclear - Unclear Verapamil [1]
MR005645 Verapamil metabolite D-617 Verapamil metabolite PR-25 Oxidation - O-demethylation Verapamil hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010530 D-702 D-620 Unclear - Unclear Verapamil [1]
MR005648 Norverapamil Verapamil metabolite D-620 Oxidation - N-dealkylation Verapamil hydrochloride [1]
MR010525 Norverapamil D-620 Unclear - Unclear Verapamil [1]
MR005651 O-Desmethylverapamil (D-702) Verapamil metabolite D-620 Oxidation - N-dealkylation Verapamil hydrochloride [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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