Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010526)
Formula
SVG example
Unclear
Reactant Verapamil Product D-617
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010529 Verapamil D-702 Unclear - Unclear Verapamil [1]
MR010531 Verapamil N19 (D-703) Unclear - Unclear Verapamil [1]
MR010523 Verapamil Norverapamil Unclear - Unclear Verapamil [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005644 Verapamil hydrochloride Verapamil metabolite D-617 Oxidation - N-dealkylation Verapamil hydrochloride [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010528 D-617 D-620 Unclear - Unclear Verapamil [1]
MR010527 D-617 PR 25 Unclear - Unclear Verapamil [1]
MR005646 Verapamil metabolite D-617 Verapamil metabolite D-620 Oxidation - N-dealkylation Verapamil hydrochloride [1]
MR005645 Verapamil metabolite D-617 Verapamil metabolite PR-25 Oxidation - O-demethylation Verapamil hydrochloride [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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