Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005649)
Formula
SVG example
O-demethylation
Reactant Norverapamil Product Verapamil metabolite D-715
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010523 Verapamil Norverapamil Unclear - Unclear Verapamil [1]
MR005647 Verapamil hydrochloride Norverapamil Oxidation - N-demethylation Verapamil hydrochloride [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010525 Norverapamil D-620 Unclear - Unclear Verapamil [1]
MR010524 Norverapamil D-715 (PR-22) Unclear - Unclear Verapamil [1]
MR005648 Norverapamil Verapamil metabolite D-620 Oxidation - N-dealkylation Verapamil hydrochloride [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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