Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010523)
Formula
CYP2C8 ...
SVG example
Unclear
Reactant Verapamil Product Norverapamil
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010526 Verapamil D-617 Unclear - Unclear Verapamil [1]
MR010529 Verapamil D-702 Unclear - Unclear Verapamil [1]
MR010531 Verapamil N19 (D-703) Unclear - Unclear Verapamil [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005647 Verapamil hydrochloride Norverapamil Oxidation - N-demethylation Verapamil hydrochloride [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010525 Norverapamil D-620 Unclear - Unclear Verapamil [1]
MR010524 Norverapamil D-715 (PR-22) Unclear - Unclear Verapamil [1]
MR005648 Norverapamil Verapamil metabolite D-620 Oxidation - N-dealkylation Verapamil hydrochloride [1]
MR005649 Norverapamil Verapamil metabolite D-715 Oxidation - O-demethylation Verapamil hydrochloride [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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