Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005648)
Formula
SVG example
N-dealkylation
Reactant Norverapamil Product Verapamil metabolite D-620
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010523 Verapamil Norverapamil Unclear - Unclear Verapamil [1]
MR005647 Verapamil hydrochloride Norverapamil Oxidation - N-demethylation Verapamil hydrochloride [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010524 Norverapamil D-715 (PR-22) Unclear - Unclear Verapamil [1]
MR005649 Norverapamil Verapamil metabolite D-715 Oxidation - O-demethylation Verapamil hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010528 D-617 D-620 Unclear - Unclear Verapamil [1]
MR010530 D-702 D-620 Unclear - Unclear Verapamil [1]
MR005651 O-Desmethylverapamil (D-702) Verapamil metabolite D-620 Oxidation - N-dealkylation Verapamil hydrochloride [1]
MR005646 Verapamil metabolite D-617 Verapamil metabolite D-620 Oxidation - N-dealkylation Verapamil hydrochloride [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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