General Information of This Metabolic Reaction (MR) (ID: MR006323)
Formula Reactant Gamma-thiobutyrolactone Product Unclear
Reactant Info Product Info
Metabolic Enzyme Serum paraoxonase/arylesterase 1 (PON1) DME Info
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000112 Albendazole . Oxidation - Oxidation Albendazole [1]
MR000127 Alfuzosin hydrochloride . Oxidation - O-Demethylations Alfuzosin hydrochloride [2]
MR007485 Anthraflavic acid Unclear Unclear Anthraflavic acid [3]
MR007253 ANW-43980 Unclear Unclear ANW-43980 [4]
MR007266 ARQ-501 Unclear Oxidation - Oxidationn ARQ-501 [5]
MR007278 AV-650 Unclear Unclear AV-650 [6]
MR005428 Avapritinib Unclear Unclear Avapritinib [7]
MR007285 AZD-2014 Unclear Unclear AZD-2014 [8]
MR007497 Azetirelin Unclear Hydrolysis - Hydrolysis Azetirelin [9]
MR007294 BC-3781 Unclear Unclear BC-3781 [10]
MR007303 BIIB-014 Unclear Unclear BIIB-014 [11]
MR012650 BMS-275183 Unclear Unclear - Unclear BMS-275183 [12]
MR000396 BNP-1350 . Unclear BNP-1350 [13]
MR005754 Brexanolone Unclear Reduction - Reduction Brexanolone [14]
MR007573 BRN-3548355 Unclear Unclear BRN-3548355 [15]
MR014091 BRN-3548355 Unclear Unclear BRN-3548355 [15]
MR007576 Bromazepam Unclear Unclear Bromazepam [16]
MR007580 Bufuralol Unclear Unclear Bufuralol [17]
MR007582 Bupranolol Unclear Unclear Bupranolol [18]
MR007393 CBL-0102 Unclear Oxidation - N-desethylation CBL-0102 [19]
MR007411 CERC-801 Unclear Unclear CERC-801 [20]
MR000608 Cetirizine . Oxidation - O-Dealkylation Cetirizine [21]
MR006255 Chloroxylenol Unclear Unclear Chloroxylenol [22]
MR000654 Choline salicylate . Oxidation - Hydroxylation Choline salicylate [23]
MR000667 CKD-501 . Unclear CKD-501 [24]
MR005296 CL-205086 Unclear Reduction - Reduction CL-205086 [25]
MR006006 Clotiazepam Unclear Unclear Clotiazepam [26]
MR005750 Clotrimazole Unclear Unclear Clotrimazole [27]
MR013654 Conivaptan hydrochloride Unclear Unclear Conivaptan hydrochloride [28]
MR005798 Coumaranone Unclear Unclear Coumaranone [29]
MR005797 CS-6969 Unclear Unclear CS-6969 [30]
MR005796 CTK1G9578 Unclear Unclear CTK1G9578 [31]
MR005326 DACTHF Unclear Unclear DACTHF [32]
MR007072 Daidzein Unclear Conjugation - Sulfation Daidzein [33]
MR005327 Decanal Unclear Unclear Decanal [34]
MR005332 Dehydrocorticosterone Unclear Reduction - Reduction Dehydrocorticosterone [35]
MR007111 Dextropropoxyphene Unclear Oxidation - Aromatic hydroxylation Dextropropoxyphene [36]
MR006289 Dichloroindophenol Unclear Unclear Dichloroindophenol [37]
MR000828 Dicumarol . Unclear Dicumarol [38]
MR007113 Dienogest Unclear Unclear Dienogest [39]
MR007114 Dihydralazine Unclear Unclear Dihydralazine [40]
MR000862 Dihydroergotamine . Unclear Dihydroergotamine [41]
MR000871 Dinoprostone . Unclear Dinoprostone [42]
MR003410 Diphenylpyraline . Oxidation - Hydroxylation Diphenylpyraline [43]
MR006018 DMI-bisphosphate Unclear Unclear DMI-bisphosphate [44]
MR000891 Docetaxel . Unclear Docetaxel [45]
MR007446 E-7070 Unclear Unclear E-7070 [46]
MR002845 Elbasvir . Unclear Elbasvir [47]
MR007137 Ephedrin Unclear Unclear Ephedrin [48]
MR007138 Ergometrine Unclear Unclear Ergometrine [49]
MR007139 Ergonovine maleate Unclear Unclear Ergonovine maleate [49]
MR000928 Eribulin . Unclear Eribulin [50]
MR007140 Esmirtazapine Unclear Unclear Esmirtazapine [51]
MR007448 Estol-1581 Unclear Hydrolysis - Hydrolysis Estol-1581 [52]
MR007453 Ethanol Unclear Unclear Ethanol [22]
MR014077 Ethinylestradiol propanesulfonate Unclear Oxidation - 16alpha-hydroxylation Ethinylestradiol propanesulfonate [53], [54]
MR001002 Exemestane . Oxidation - Oxidation Exemestane [55], [56]
MR001011 Fedratinib hydrochloride . Unclear Fedratinib hydrochloride [57], [58]
MR001025 Fentanyl citrate . Unclear Fentanyl citrate [45]
MR007189 Ferrum metallicum Unclear Unclear Ferrum metallicum [59]
MR001038 Finasteride . Unclear Finasteride [45]
MR001043 Fingolimod . Unclear Fingolimod [60]
MR001048 Fingolimod hydrochloride . Unclear Fingolimod hydrochloride [60]
MR013655 Fluprednisolone Unclear Unclear Fluprednisolone [61]
MR006970 FT-0654944 Unclear Unclear FT-0654944 [62]
MR007455 FYX-051 Unclear Oxidation - 2-hydroxylation FYX-051 [63]
MR006322 Gamma-butyrolactone Unclear Unclear Gamma-butyrolactone [29]
MR005973 GBR-12909 Unclear Unclear GBR-12909 [64]
MR007214 Gestodene Unclear Unclear Gestodene [65]
MR007229 Gliquidone Unclear Unclear Gliquidone [66]
MR007230 Glucosamine Unclear Unclear Glucosamine [67]
MR007004 Glucose-bisphosphate Unclear Unclear Glucose-bisphosphate [68]
MR007457 Glutathiol Unclear Unclear Glutathiol [69]
MR007235 Glyceryl trinitrate Unclear Unclear Glyceryl trinitrate [70]
MR007240 Grazoprevir Unclear Unclear Grazoprevir [71]
MR007468 GS-9620 Unclear Oxidation - Hydrolyzationn GS-9620 [72]
MR007471 GSK-1278863 Unclear Unclear GSK-1278863 [73]
MR006971 GTPL-989 Unclear Other reaction - Degradation GTPL-989 [74]
MR007241 Guanoxan Unclear Oxidation - Hydrolyzationn Guanoxan [22]
MR005980 GW-873140 Unclear Unclear GW-873140 [75]
MR005784 Halcinonide Unclear Unclear Halcinonide [76]
MR007037 Homogentisic acid Unclear Hydrolysis - Hydrolysis Homogentisic acid [29]
MR006130 HSDB-3165 Unclear Unclear HSDB-3165 [77]
MR007044 Hydroxy-cholesten-one Unclear Hydrolysis - Hydrolysis Hydroxy-cholesten-one [78]
MR007043 Hydroxybutyryl-CoA Unclear Hydrolysis - Hydrolysis Hydroxybutyryl-CoA [78]
MR005774 Iclaprim Unclear Unclear Iclaprim [79]
MR005775 Imiquimod Unclear Unclear Imiquimod [22]
MR007506 Indan-1-ol Unclear Oxidation - Oxidationn Indan-1-ol [80]
MR005514 Infigratinib Unclear Oxidation - Hydrolyzationn Infigratinib [81], [82]
MR007513 Inosine Unclear Unclear Inosine [83], [84]
MR007519 Insulin Unclear Unclear Insulin [85]
MR005335 Isatin Unclear Reduction - Reduction Isatin [86]
MR002854 Isavuconazole . Unclear Isavuconazole [87], [88]
MR005338 K-6015 Unclear Unclear K-6015 [89]
MR006983 Kestose Unclear Oxidation - Hydrolyzationn Kestose [90]
MR005869 L-thyroxine Unclear Unclear L-thyroxine [91]
MR005363 Lactate Unclear Unclear Lactate [92]
MR001433 Lefamulin . Unclear Lefamulin [93], [94], [95]
MR003105 Leflunomide . Unclear Leflunomide [96]
MR005523 Lenacapavir Unclear Unclear Lenacapavir [97]
MR001442 Lenvatinib mesylate . Unclear Lenvatinib mesylate [98]
MR001444 Letermovir . Unclear Letermovir [99]
MR003114 Levomethadyl acetate hydrochloride . Unclear Levomethadyl acetate hydrochloride [45]
MR001514 Levonorgestrel . Unclear Levonorgestrel [100]
MR001555 Lidocaine . Unclear Lidocaine [101]
MR001580 Liraglutide . Oxidation - Degradation Liraglutide [102]
MR005870 Lorpiprazole Unclear Unclear Lorpiprazole [103]
MR006140 LY-2940680 Unclear Unclear LY-2940680 [104], [105]
MR005858 Malate Unclear Unclear Malate [106], [107]
MR005856 Man-b-4MU Unclear Unclear Man-b-4MU [108]
MR005855 Manidipine 2HCl Unclear Unclear Manidipine 2HCl [109]
MR005853 Mannose Unclear Unclear Mannose [110]
MR005850 Mannotetraose Unclear Unclear Mannotetraose [108]
MR005837 Medrogestone Unclear Oxidation - Hydrolyzationn Medrogestone [111]
MR005836 Melibiose Unclear Unclear Melibiose [112]
MR005749 Methylergometrine Unclear Unclear Methylergometrine [113]
MR006019 Miocamycin Unclear Oxidation - Hydrolyzationn Miocamycin [114]
MR005538 Mitapivat Unclear Unclear Mitapivat [115]
MR012690 MK-3118 Unclear Oxidation - Hydroxylation MK-3118 [116]
MR005785 MLN-8054 Unclear Unclear MLN-8054 [117]
MR005404 MRTX849 Unclear Unclear MRTX849 [118]
MR006386 NSC-9705 Unclear Unclear NSC-9705 [74]
MR002863 Oxazepam . Oxidation - Deamination Oxazepam [119]
MR012697 Phenylethylamine Unclear Unclear - Unclear Phenylethylamine [120]
MR012707 Phloretin Unclear Conjugation - Glucuronidation Phloretin [3]
MR010738 Plecanatide Unclear Unclear - Unclear Plecanatide [121]
MR005804 Prasterone sulfate Unclear Unclear Prasterone sulfate [122]
MR002134 Pretomanid . Unclear Pretomanid [123]
MR007610 Provitamin D3 Unclear Oxidation - Oxidationn Provitamin D3 [124]
MR005431 PT2977 Unclear Unclear PT2977 [125]
MR005205 Pyrantel Unclear Unclear Pyrantel [126]
MR006988 Q-44287045 Unclear Unclear Q-44287045 [127]
MR007662 R-58735 Unclear Conjugation - Glucuronidation R-58735 [128]
MR005213 Ramosetron Unclear Unclear Ramosetron [129], [130]
MR009513 Rasagiline mesylate Unclear Unclear - Unclear Rasagiline mesylate [131]
MR005585 Relugolix Unclear Unclear Relugolix [132]
MR005235 Remoxipride Unclear Unclear Remoxipride [22]
MR006357 Repinotan Unclear Unclear Repinotan [133]
MR009530 Revefenacin Unclear Unclear - Unclear Revefenacin [134]
MR013061 Rifabutin Unclear Unclear - Unclear Rifabutin [135]
MR013474 Rifaximin Unclear Unclear Rifaximin [136]
MR007663 RO-408757 Unclear Unclear RO-408757 [137]
MR002894 Selinexor . Unclear Selinexor [138]
MR005635 Selpercatinib Unclear Unclear Selpercatinib [139]
MR002243 Semaglutide . Hydrolysis - Hydrolysis Semaglutide [140]
MR013437 Simvastatin Unclear Unclear Simvastatin [141]
MR006816 Sisomicin Unclear Unclear Sisomicin [142]
MR005264 Sitaxentan Unclear Unclear Sitaxentan [143]
MR006839 Spectinomycin Unclear Conjugation - O-Adenosine conjugation Spectinomycin [144]
MR005894 Sudan I Unclear Unclear Sudan I [145]
MR002354 Tecovirimat . Hydrolysis - Hydrolysis Tecovirimat [146]
MR002361 Tegaserod . Hydrolysis - Hydrolysis Tegaserod [147]
MR002364 Telaprevir . Reduction - Reduction Telaprevir [148]
MR002388 Temsirolimus . Unclear Temsirolimus [45]
MR002398 Teniposide . Unclear Teniposide [45]
MR011029 Thiazolidinedione Unclear Unclear - Unclear Thiazolidinedione [149]
MR006182 Tianeptine Unclear Unclear Tianeptine [150]
MR006149 TMC-120 Unclear Unclear TMC-120 [151]
MR002452 Trifarotene . Unclear Trifarotene [152]
MR006485 TXA-127 Unclear Hydrolysis - Hydrolysis TXA-127 [153]
MR002472 Upadacitinib . Conjugation - Glucuronidation Upadacitinib [154]
MR005675 Voxelotor Unclear Oxidation - Oxidationn Voxelotor [155]
MR013252 Voxilaprevir Unclear Unclear Voxilaprevir [156]
MR007001 W-201259 Unclear Unclear W-201259 [108]
MR006070 XL-147 Unclear Oxidation - Oxidationn XL-147 [157], [158]
MR006498 Y-100032 Unclear Unclear Y-100032 [159]
MR006153 ZK-299 Unclear Oxidation - Oxidationn ZK-299 [160]
MR002356 . . Oxidation - Oxidation Tegaserod [147]
MR001467 3-hydroxy levobupivacaine . Conjugation - Glucuronidation Levobupivacaine [161]
MR007162 8-hydroxy-etizolam Unclear Conjugation - Conjugation Etizolam [162]
MR006868 AGI-16903 Unclear Unclear Enasidenib [163]
MR007160 alpha-hydroxyetizolam Unclear Conjugation - Conjugation Etizolam [162]
MR005177 Amino-metabolite Unclear Unclear Pirprofen [164]
MR000840 Digitoxigenin-monodigitoxoside . Unclear Digitoxin [165]
MR000841 Epidigitoxigenin . Conjugation - Conjugation Digitoxin [166]
MR005178 Epoxide metabolite Unclear Conjugation - Glucuronidation Pirprofen [164]
MR001039 Fingolimod carboxylic acid metabolite . Oxidation - Oxidation Fingolimod [167]
MR001044 Fingolimod carboxylic acid metabolite . Oxidation - Oxidation Fingolimod hydrochloride [167]
MR007237 Fragments Unclear Unclear Hyaluronan [168]
MR007329 Glutathione conjugation Unclear Unclear BP-12941 [169]
MR000447 Glycyrrhetinic acid . Conjugation - Glucuronidation BRN-0077922 [170]
MR007462 GS-9620 M12 Unclear Oxidation - Hydrolyzationn GS-9620 [72]
MR002333 hydroxy tapentado . Conjugation - Conjugation Tapentadol [171]
MR002794 Isavuconazole . Unclear Isavuconazonium [88]
MR005852 Mannose-6-phosphate Unclear Unclear Mannose [110]
MR001049 Meta-O-dealkylated flecainide . Unclear Flecainide acetate [172]
MR001050 Meta-O-dealkylated lactam . Unclear Flecainide acetate [172]
MR007625 O-quinone Unclear Conjugation - Conjugation Pyrocatechol [173]
MR007298 Paracetamol Unclear Unclear BCP-13498 [174]
MR014085 Paracetamol Unclear Unclear BCP-13498 [175]
MR002390 Sirolimus . Unclear Temsirolimus [176]
MR007112 Unclear Unclear Conjugation - Conjugation Dextropropoxyphene [36]
MR012651 Unclear Unclear Unclear - Unclear BMS-275183 [12]
MR012691 Unclear Unclear Conjugation - Glucuronidation MK-3118 [177]
MR002792 . . Conjugation - Glucuronidation Isavuconazonium [178]
MR000883 Diethyldithiocarbamic acid methyl ester . Oxidation - Sulfoxidation Disulfiram [179]
MR007460 GS-9620 M18 Unclear Oxidation - Hydrolyzationn GS-9620 [72]
MR006177 Tianeptine metabolite N Unclear Oxidation - N-dealkylation Tianeptine [180], [181]
MR007330 Unclear Unclear Unclear BP-12941 [169]
MR000875 Diphenylmethoxyacetic acid . Conjugation - Conjugation Diphenhydramine [176]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002356 . . Oxidation - Oxidation Tegaserod [147]
MR007154 Unclear 16alpha-methoxyethinylestradiol Conjugation - O-methylation Ethinylestradiol propanesulfonate [53], [54]
MR007142 Unclear 2-methoxyethinylestradiol Conjugation - O-methylation Ethinylestradiol propanesulfonate [53], [54]
MR007145 Unclear 4-methoxyethinylestradiol Conjugation - O-methylation Ethinylestradiol propanesulfonate [53], [54]
MR007148 Unclear 6-methoxyethinylestradiol Conjugation - O-methylation Ethinylestradiol propanesulfonate [53], [54]
MR007151 Unclear 7-methoxyethinylestradiol Conjugation - O-methylation Ethinylestradiol propanesulfonate [53], [54]
MR010740 Unclear Amino acids Unclear - Unclear Plecanatide [121]
MR007269 Unclear ARQ-501 M3-1 Conjugation - Glucuronidation ARQ-501 [5]
MR007270 Unclear ARQ-501 M3-2 Conjugation - Glucuronidation ARQ-501 [5]
MR007267 Unclear ARQ-501 M4-1 Multi-steps Reaction - Reduction; glucuronidation ARQ-501 [5]
MR007268 Unclear ARQ-501 M4-2 Multi-steps Reaction - Reduction; glucuronidation ARQ-501 [5]
MR011034 Unclear PTC1 Unclear - Unclear Thiazolidinedione [149]
MR011030 Unclear PTC5 Unclear - Unclear Thiazolidinedione [149]
MR011031 Unclear PTC6 Unclear - Unclear Thiazolidinedione [149]
MR010739 Unclear Small peptides Unclear - Unclear Plecanatide [121]
MR007112 Unclear Unclear Conjugation - Conjugation Dextropropoxyphene [36]
MR012651 Unclear Unclear Unclear - Unclear BMS-275183 [12]
MR012691 Unclear Unclear Conjugation - Glucuronidation MK-3118 [177]
MR002792 . . Conjugation - Glucuronidation Isavuconazonium [178]
MR002355 . 5-methoxyindole-3-carboxylic acid Conjugation - Conjugation Tegaserod [147]
MR005199 Unclear Benzilic acid Unclear Propiverine [182]
MR012653 Unclear BMS-275183 Metabolite M20 Unclear - Unclear BMS-275183 [12]
MR012654 Unclear BMS-275183 Metabolite M20B Unclear - Unclear BMS-275183 [12]
MR012652 Unclear BMS-275183 Metabolite M22 Unclear - Unclear BMS-275183 [12]
MR007330 Unclear Unclear Unclear BP-12941 [169]
MR007331 Unclear Mercapturic acid Conjugation - Acetylation BP-12941 [169]
MR006178 Unclear Tianeptine metabolite P Reduction - Reduction Tianeptine [180], [181]
⏷ Show the Full List of MR
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72 Metabolism of vesatolimod in rat, dog, and human liver microsomes: Metabolic stability assessment, metabolite identification, and interspecies comparison
73 Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects. Drug Metab Pharmacokinet. 2015 Dec;30(6):410-8.
74 Studies on pharmacokinetic drug interaction potential of vinpocetine. Medicines (Basel). 2015 Jun 5;2(2):93-105.
75 The effects of ritonavir and lopinavir/ritonavir on the pharmacokinetics of a novel CCR5 antagonist, aplaviroc, in healthy subjects
76 NCI Thesaurus (NCIt): Halcinonide
77 Rare mutations in renal sodium and potassium transporter genes exhibit impaired transport function. Curr Opin Nephrol Hypertens. 2014 Jan;23(1):1-8.
78 The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry. 2009 Feb 17;48(6):1293-304.
79 An updated review of iclaprim: a potent and rapidly bactericidal antibiotic for the treatment of skin and skin structure infections and nosocomial pneumonia caused by gram-positive including multidrug-resistant bacteria. Open Forum Infect Dis. 2018 Jan 6;5(2):ofy003.
80 Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione. Biochemistry. 1998 May 12;37(19):6781-90.
81 Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4
82 Identification of Infigratinib as a Potent Reversible Inhibitor and Mechanism-Based Inactivator of CYP2J2: Nascent Evidence for a Potential In Vivo Metabolic Drug-Drug Interaction with Rivaroxaban
83 Metabolism of nicotinamide, adenine and inosine in developing microspore-derived canola (Brassica napus) embryos
84 Inosine in Biology and Disease
85 Vibrio vulnificus secretes an insulin-degrading enzyme that promotes bacterial proliferation in vivo. J Biol Chem. 2015 Jul 24;290(30):18708-20.
86 Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis. Chem Biol Interact. 2009 Mar 16;178(1-3):234-41.
87 Pharmacokinetic evaluation of CYP3A4-mediated drug-drug interactions of isavuconazole with rifampin, ketoconazole, midazolam, and ethinyl estradiol/norethindrone in healthy adults. Clin Pharmacol Drug Dev. 2017 Jan;6(1):44-53.
88 Concomitant use of isavuconazole and CYP3A4/5 inducers: Where pharmacogenetics meets pharmacokinetics Mycoses. 2021 Sep;64(9):1111-1116. doi: 10.1111/myc.13300.
89 Comparison of anti-Campylobacter activity of free thymol and thymol-beta-D-glucopyranoside in absence or presence of beta-glycoside-hydrolysing gut bacteria. Food Chem. 2015 Apr 15;173:92-8.
90 Extracellular fructooligosaccharide degradation in Anaerostipes hadrus for co-metabolism with non-fructooligosaccharide utilizers
91 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
92 Kinetic characterization of lactate dehydrogenase in normal and malignant human breast tissues. Cancer Cell Int. 2015 Feb 15;15:19.
93 Lefamulin: review of a promising novel pleuromutilin antibiotic. Pharmacotherapy. 2018 Sep;38(9):935-946.
94 Lefamulin: a New Hope in the Field of Community-Acquired Bacterial Pneumonia. Curr Pharmacol Rep. 2022;8(6):418-426. doi: 10.1007/s40495-022-00297-6.
95 Development, validation, and application of an LC-MS/MS method for the quantification of the novel antibiotic drug lefamulin (Xenleta?) and its main metabolite 2R-hydroxy lefamulin in human plasma. J Pharm Biomed Anal. 2021 Oct 25;205:114293. doi: 10.1016/j.jpba.2021.114293.
96 Leflunomide-induced acute hepatitis. Dig Liver Dis. 2004 Jan;36(1):82-4.
97 FDA label:Lenacapavir
98 Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer. Sci Rep. 2019 Apr 1;9(1):5404.
99 Absorption, Metabolism, Distribution, and Excretion of Letermovir Curr Drug Metab. 2021;22(10):784-794. doi: 10.2174/1389200222666210223112826.
100 [Influence of CYP3A4/5 polymorphisms in the pharmacokinetics of levonorgestrel: a pilot study]. Biomedica. 2012 Oct-Dec;32(4):570-7.
101 Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65.
102 Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase. Drug Metab Dispos. 2010 Nov;38(11):1944-53.
103 [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]. Psychiatr Pol. 2011 Jul-Aug;45(4):611-25.
104 Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors
105 Phase I study of LY2940680, a Smo antagonist, in patients with advanced cancer including treatment-naive and previously treated basal cell carcinoma. Clin Cancer Res. 2018 May 1;24(9):2082-2091.
106 Thermostable, ammonium-activated malic enzyme of Clostridium thermocellum. Biochim Biophys Acta. 1981 Aug 13;660(2):251-5.
107 The correlation between Clostridium-difficile infection and human gut concentrations of Bacteroidetes phylum and clostridial species. Eur J Clin Microbiol Infect Dis. 2014 Mar;33(3):377-83.
108 Structure and function of Bs164 beta-mannosidase from Bacteroides salyersiae the founding member of glycoside hydrolase family GH164. J Biol Chem. 2020 Mar 27;295(13):4316-4326.
109 Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects. Br J Clin Pharmacol. 2006 May;61(5):533-7.
110 Mannose metabolism: more than meets the eye. Biochem Biophys Res Commun. 2014 Oct 17;453(2):220-8.
111 DrugBank(Pharmacology-Metabolism):Medrogestone
112 Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8.
113 Modulation of cytochrome P450 metabolism by ergonovine and dihydroergotamine. Vet Hum Toxicol. 2003 Feb;45(1):6-9.
114 Studies on the cytochrome P450 (CYP)-mediated metabolic properties of miocamycin: evaluation of the possibility of a metabolic intermediate complex formation with CYP, and identification of the human CYP isoforms
115 DrugBank(Pharmacology-Metabolism):Mitapivat
116 Ibrexafungerp: A Novel Oral Triterpenoid Antifungal in Development for the Treatment of Candida auris Infections
117 MLN8054 and Alisertib (MLN8237): discovery of selective oral aurora A inhibitors. ACS Med Chem Lett. 2015 Apr 22;6(6):630-4.
118 DrugBank(Pharmacology-Metabolism):Adagrasib
119 Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures. Xenobiotica. 2000 Jan;30(1):27-46.
120 The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57.
121 Plecanatide for the treatment of chronic idiopathic constipation in adult patients
122 CYP3A7*1C polymorphism, serum dehydroepiandrosterone sulfate level, and bone mineral density in postmenopausal women. Calcif Tissue Int. 2007 Mar;80(3):154-9.
123 FDA:Pretomanid
124 Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism. J Steroid Biochem Mol Biol. 2017 May;169:202-209.
125 FDA label:Belzutifan
126 Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42.
127 A bacterial glycosyltransferase gene toolbox: generation and applications. Phytochemistry. 2009 Oct-Nov;70(15-16):1812-21.
128 Pharmacokinetics of sabeluzole and dextromethorphan oxidation capacity in patients with severe hepatic dysfunction and healthy volunteers. Br J Clin Pharmacol. 2001 Feb;51(2):164-8.
129 Management of postoperative nausea and vomiting: focus on palonosetron
130 Ondansetron, ramosetron, or palonosetron: which is a better choice of antiemetic to prevent postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy? Anesth Essays Res. 2011 Jul-Dec;5(2):182-6.
131 Pharmacokinetic interaction study between flavanones (hesperetin, naringenin) and rasagiline mesylate in wistar rats
132 An Efficient UPLC-MS/MS Method Established to Detect Relugolix Concentration in Rat Plasma
133 Evaluation of interethnic differences in repinotan pharmacokinetics by using population approach. Drug Metab Pharmacokinet. 2006 Feb;21(1):61-9.
134 A 28-day, randomized, double-blind, placebo-controlled, parallel group study of nebulized revefenacin in patients with chronic obstructive pulmonary disease. Respir Res. 2017 Nov 2;18(1):182.
135 The effect of multiple doses of ritonavir on the pharmacokinetics of rifabutin. Clin Pharmacol Ther. 1998 Apr;63(4):414-21.
136 U. S. FDA Label -Rifaximin
137 Metabolism of mofarotene in hepatocytes and liver microsomes from different species. Comparison with in vivo data and evaluation of the cytochrome P450 isoenzymes involved in human biotransformation. Drug Metab Dispos. 1995 Oct;23(10):1051-7.
138 FDA label of Selinexor. The 2020 official website of the U.S. Food and Drug Administration.
139 P-Glycoprotein (ABCB1/MDR1) and BCRP (ABCG2) Limit Brain Accumulation and Cytochrome P450-3A (CYP3A) Restricts Oral Exposure of the RET Inhibitor Selpercatinib (RETEVMO)
140 Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species. Eur J Pharm Sci. 2017 Jun 15;104:31-41.
141 Simvastatin Tablet, Film-Coated
142 Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen. Antimicrob Agents Chemother. 2013 Jan;57(1):452-7.
143 Interaction of acenocoumarol and sitaxentan in pulmonary arterial hypertension. Eur J Clin Invest. 2009 Jun;39 Suppl 2:14-8.
144 Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica. J Biol Chem. 2018 Jul 20;293(29):11481-11490.
145 Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes
146 LABEL:POXX- tecovirimat monohydrate injection, solution, concentrate TPOXX- tecovirimat monohydrate capsule
147 Clinical pharmacokinetics of tegaserod, a serotonin 5-HT(4) receptor partial agonist with promotile activity Clin Pharmacokinet. 2002;41(13):1021-42. doi: 10.2165/00003088-200241130-00002.
148 NCIVEK- telaprevir tablet, film coated Vertex Pharmaceuticals Incorporated
149 Species and gender differences in the formation of an active metabolite of a substituted 2,4-thiazolidinedione insulin sensitizer
150 Tianeptine: a facilitator of the reuptake of serotonin and norepinephrine as an antidepressant? J Psychiatr Pract. 2004 Sep;10(5):323-30.
151 Investigating the Contribution of Drug-Metabolizing Enzymes in Drug-Drug Interactions of Dapivirine and Miconazole
152 LABEL:KLIEF- trifarotene cream
153 Metabolism of angiotensin-(1-7) by angiotensin-converting enzyme. Hypertension. 1998 Jan;31(1 Pt 2):362-7.
154 LABEL:INVOQ- upadacitinib tablet, extended release
155 FDA Approved Drug Products:Oxbryta (voxelotor) tablets
156 FDA Label of Vosevi. The 2020 official website of the U.S. Food and Drug Administration
157 Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes. Drug Metab Dispos. 2012 Feb;40(2):267-75.
158 Aldehyde oxidase and its role as a drug metabolizing enzyme
159 In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug. Invest New Drugs. 2007 Feb;25(1):9-19.
160 Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use. J Pharmacokinet Biopharm. 1997 Dec;25(6):647-72.
161 Clinical profile of levobupivacaine in regional anesthesia: A systematic review. J Anaesthesiol Clin Pharmacol. 2013 Oct;29(4):530-9.
162 erowid:Etizolam
163 FDA:Enasidenib
164 High-performance liquid chromatographic determination of pirprofen and five of its metabolites in human plasma without hydrolysis and in human urine before and after chemical hydrolysis
165 Hydroxysteroid sulfotransferase and a specific UDP-glucuronosyltransferase are involved in the metabolism of digitoxin in man. Naunyn Schmiedebergs Arch Pharmacol. 1992 Aug;346(2):226-33.
166 Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY:Elsevier Science Publishing Co., Inc. 1988., p. 201
167 CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis. Drug Metab Dispos. 2011 Feb;39(2):191-8.
168 Hyaluronan: Metabolism and Function
169 Pharmacokinetics and pharmacodynamics of phenethyl isothiocyanate: implications in breast cancer prevention. AAPS J. 2014 Jul;16(4):705-13.
170 DrugBank(Pharmacology-Metabolism)BRN-0077922
171 LABEL:UCYNTA- tapentadol hydrochloride tablet, film coated
172 Metabolism of flecainide Am J Cardiol. 1984 Feb 27;53(5):41B-51B. doi: 10.1016/0002-9149(84)90501-0.
173 Assessment of the metabolism and intrinsic reactivity of a novel catechol metabolite
174 Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics. 2004 Aug;14(8):487-99.
175 Polymorphic expression of UGT1A9 is associated with variable acetaminophen glucuronidation in neonates: a population pharmacokinetic and pharmacogenetic study. Clin Pharmacokinet. 2018 Oct;57(10):1325-1336.
176 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511
177 LABEL:BREXAFEMME- ibrexafungerp tablet, film coated
178 DrugBank(Pharmacology-Metabolism)Isavuconazonium
179 Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: role of P-450 enzymes in disulfiram bioactivation. Alcohol Clin Exp Res. 1998 Sep;22(6):1212-9.
180 Ion-pair extraction and high-performance liquid chromatographic determination of tianeptine and its metabolites in human plasma, urine and tissues
181 The metabolic pathways of tianeptine, a new antidepressant, in healthy volunteers
182 Pharmacokinetic Studies on Propiverine Hydrochloride

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