Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006575)
Formula
SVG example
Reactant 8-hydroxyclomipramine Product 8-hydroxydesmethyl clomipramine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009005 Clomipramine 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine [1]
MR006574 Clomipramine hydrochloride 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine hydrochloride [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006577 8-hydroxyclomipramine 8-hydroxyclomipramine glucuronide Conjugation - Glucuronidation Clomipramine hydrochloride [2]
MR009008 8-hydroxyclomipramine 8-hydroxyclomipramine glucuronide Conjugation - Glucuronidation Clomipramine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006576 8-hydroxydesmethyl clomipramine 8-hyroxydesmethyl clomipramine glucuronide Conjugation - Glucuronidation Clomipramine hydrochloride [2]
MR009007 8-hydroxydesmethyl clomipramine 8-hyroxydesmethyl clomipramine glucuronide Unclear - Unclear Clomipramine [1]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Metabolism of clomipramine in a Japanese psychiatric population: hydroxylation, desmethylation, and glucuronidation

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