Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009008)
Formula Reactant 8-hydroxyclomipramine Product 8-hydroxyclomipramine glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009005 Clomipramine 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine [1]
MR006574 Clomipramine hydrochloride 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine hydrochloride [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006575 8-hydroxyclomipramine 8-hydroxydesmethyl clomipramine Unclear Clomipramine hydrochloride [2]
MR009006 8-hydroxyclomipramine 8-hydroxydesmethyl clomipramine Unclear - Unclear Clomipramine [1], [3]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Metabolism of clomipramine in a Japanese psychiatric population: hydroxylation, desmethylation, and glucuronidation
3 The effect of CYP2C19 and CYP2D6 genotypes on the metabolism of clomipramine in Japanese psychiatric patients. J Clin Psychopharmacol. 2001 Dec;21(6):549-55.

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