Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009005)
Formula
SVG example
8-hydroxylation
Reactant Clomipramine Product 8-hydroxyclomipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - 8-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009013 Clomipramine 10-OH-clomipramine Oxidation - Aliphatic hydroxylation Clomipramine [1]
MR009001 Clomipramine 2-hydroxyclomipramine Oxidation - 2-hydroxylation Clomipramine [1]
MR009012 Clomipramine 8-OH-clomipramine Oxidation - Aromatic hydroxylation Clomipramine [1]
MR009011 Clomipramine Clomipramine N-oxide Unclear - Unclear Clomipramine [2]
MR009009 Clomipramine Desmethylclomipramine Oxidation - N-demethylation Clomipramine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006574 Clomipramine hydrochloride 8-hydroxyclomipramine Oxidation - 8-hydroxylation Clomipramine hydrochloride [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006577 8-hydroxyclomipramine 8-hydroxyclomipramine glucuronide Conjugation - Glucuronidation Clomipramine hydrochloride [3]
MR009008 8-hydroxyclomipramine 8-hydroxyclomipramine glucuronide Conjugation - Glucuronidation Clomipramine [1]
MR006575 8-hydroxyclomipramine 8-hydroxydesmethyl clomipramine Unclear Clomipramine hydrochloride [3]
MR009006 8-hydroxyclomipramine 8-hydroxydesmethyl clomipramine Unclear - Unclear Clomipramine [1], [4]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 DrugBank(Pharmacology-Metabolism):Clomipramine
3 Metabolism of clomipramine in a Japanese psychiatric population: hydroxylation, desmethylation, and glucuronidation
4 The effect of CYP2C19 and CYP2D6 genotypes on the metabolism of clomipramine in Japanese psychiatric patients. J Clin Psychopharmacol. 2001 Dec;21(6):549-55.

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