Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006620)
Formula	O-dealkylation; hydroxylation
	Reactant	Donepezil hydrochloride	Product	Donepezil M1
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Oxidation - O-dealkylation; hydroxylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006622	Donepezil hydrochloride	Donepezil M2	Oxidation - Hydrolyzationn	Donepezil hydrochloride	[1], [2]
MR006624	Donepezil hydrochloride	Donepezil M4	Hydrolysis - Hydrolysis	Donepezil hydrochloride	[3]
MR006625	Donepezil hydrochloride	Donepezil M6	Oxidation - N-oxidation	Donepezil hydrochloride	[3]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006621	Donepezil M1	Donepezil M11	Conjugation - Glucuronidation	Donepezil hydrochloride	[4]

References
1	An evaluation of the pharmacokinetics of donepezil HCl in patients with moderately to severely impaired renal function
2	Donepezil in Alzheimer's disease: From conventional trials to pharmacogenetics
3	Metabolism and elimination of 14C-donepezil in healthy volunteers: a single-dose study
4	DrugBank(Pharmacology-Metabolism): Donepezil hydrochloride

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