Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006625)
Formula Reactant Donepezil hydrochloride Product Donepezil M6
Reactant Info Product Info
Metabolic Type Oxidation - N-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006620 Donepezil hydrochloride Donepezil M1 Oxidation - O-dealkylation; hydroxylation Donepezil hydrochloride [1]
MR006622 Donepezil hydrochloride Donepezil M2 Oxidation - Hydrolyzationn Donepezil hydrochloride [2], [3]
MR006624 Donepezil hydrochloride Donepezil M4 Hydrolysis - Hydrolysis Donepezil hydrochloride [1]
References
1 Metabolism and elimination of 14C-donepezil in healthy volunteers: a single-dose study
2 An evaluation of the pharmacokinetics of donepezil HCl in patients with moderately to severely impaired renal function
3 Donepezil in Alzheimer's disease: From conventional trials to pharmacogenetics

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