Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006622)
Formula
SVG example
Hydrolyzationn
Reactant Donepezil hydrochloride Product Donepezil M2
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006620 Donepezil hydrochloride Donepezil M1 Oxidation - O-dealkylation; hydroxylation Donepezil hydrochloride [1]
MR006624 Donepezil hydrochloride Donepezil M4 Hydrolysis - Hydrolysis Donepezil hydrochloride [1]
MR006625 Donepezil hydrochloride Donepezil M6 Oxidation - N-oxidation Donepezil hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006623 Donepezil M2 Donepezil M12 Conjugation - Glucuronidation Donepezil hydrochloride [2]
References
1 Metabolism and elimination of 14C-donepezil in healthy volunteers: a single-dose study
2 DrugBank(Pharmacology-Metabolism): Donepezil hydrochloride

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