Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006883)
Formula Reactant Alpha-hydroxy-amphetamine Product Phenylacetone
Reactant Info Product Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006882 D-amphetamine Alpha-hydroxy-amphetamine Oxidation - Oxidationn Lisdexamfetamine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000221 Amphetamine Phenylacetone Oxidation - Oxidative Deamination Amphetamine [2]
MR009985 Amphetamine Metamfetamine Metabolite M5 Unclear - Unclear Metamfetamine [3]
MR010001 Amphetamine Metamfetamine Metabolite M5 Unclear - Unclear Methamphetamine hydrochloride [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000218 Phenylacetone Benzoic acid Oxidation - Oxidation Amphetamine [4]
MR009986 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Metamfetamine [3]
MR010002 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Methamphetamine hydrochloride [3]
MR006884 Phenylacetone Benzoic Acid Unclear Lisdexamfetamine [1]
MR006885 Phenylacetone Hippuric acid Unclear Lisdexamfetamine [1]
References
1 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
2 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
3 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat
4 DrugBank(Pharmacology-Metabolism)Amphetamine

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