Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010001)
Formula
SVG example
Unclear
Reactant Amphetamine Product Metamfetamine Metabolite M5
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000220 Amphetamine 4-hydroxyamphetamine Oxidation - Hydroxylation Amphetamine [1]
MR000222 Amphetamine Norephedrine Oxidation - Hydroxylation Amphetamine [1]
MR009989 Amphetamine 4-Hydroxyamphetamine Unclear - Unclear Metamfetamine [2]
MR010005 Amphetamine 4-Hydroxyamphetamine Unclear - Unclear Methamphetamine hydrochloride [2]
MR009987 Amphetamine Norephedrine Unclear - Unclear Metamfetamine [2]
MR010003 Amphetamine Norephedrine Unclear - Unclear Methamphetamine hydrochloride [2]
MR007172 Amphetamine Norephedrine Norpxudoephed rine Oxidation - eta-hydroxylation Famprofazone [3]
MR007171 Amphetamine p-Hydroxyamphetamine Oxidation - p-hydroxylation Famprofazone [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006883 Alpha-hydroxy-amphetamine Phenylacetone Oxidation - Deamination Lisdexamfetamine [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000218 Phenylacetone Benzoic acid Oxidation - Oxidation Amphetamine [5]
MR009986 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Metamfetamine [2]
MR010002 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Methamphetamine hydrochloride [2]
MR006884 Phenylacetone Benzoic Acid Unclear Lisdexamfetamine [4]
MR006885 Phenylacetone Hippuric acid Unclear Lisdexamfetamine [4]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat
3 Identification of new urinary metabolites of famprofazone in humans
4 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
5 DrugBank(Pharmacology-Metabolism)Amphetamine

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