Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000221)
Formula
SVG example
Oxidative Deamination
Reactant Amphetamine Product Phenylacetone
Reactant Info Product Info
Metabolic Type Oxidation - Oxidative Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000220 Amphetamine 4-hydroxyamphetamine Oxidation - Hydroxylation Amphetamine [1]
MR000222 Amphetamine Norephedrine Oxidation - Hydroxylation Amphetamine [1]
MR009989 Amphetamine 4-Hydroxyamphetamine Unclear - Unclear Metamfetamine [2]
MR010005 Amphetamine 4-Hydroxyamphetamine Unclear - Unclear Methamphetamine hydrochloride [2]
MR009987 Amphetamine Norephedrine Unclear - Unclear Metamfetamine [2]
MR010003 Amphetamine Norephedrine Unclear - Unclear Methamphetamine hydrochloride [2]
MR007172 Amphetamine Norephedrine Norpxudoephed rine Oxidation - eta-hydroxylation Famprofazone [3]
MR007171 Amphetamine p-Hydroxyamphetamine Oxidation - p-hydroxylation Famprofazone [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006883 Alpha-hydroxy-amphetamine Phenylacetone Oxidation - Deamination Lisdexamfetamine [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000218 Phenylacetone Benzoic acid Oxidation - Oxidation Amphetamine [5]
MR009986 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Metamfetamine [2]
MR010002 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Methamphetamine hydrochloride [2]
MR006884 Phenylacetone Benzoic Acid Unclear Lisdexamfetamine [4]
MR006885 Phenylacetone Hippuric acid Unclear Lisdexamfetamine [4]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat
3 Identification of new urinary metabolites of famprofazone in humans
4 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
5 DrugBank(Pharmacology-Metabolism)Amphetamine

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