Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008597)
Formula
SVG example
Glucuronidation
Reactant Puerarin Product Puerarin-4'-O-glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008598 Puerarin Daidzein-4',7'-di-O-sulfate Conjugation - Sulfation Puerarin [1]
MR008599 Puerarin Daidzein-4'-O-sulfate Conjugation - Sulfation Puerarin [1]
MR008592 Puerarin Puerarin metabolite M21 Oxidation - Hydroxylation Puerarin [2]
MR008595 Puerarin Puerarin metabolite M37 Unclear - Unclear Puerarin [2]
MR008596 Puerarin Puerarin metabolite M4 Unclear - Unclear Puerarin [2]
MR008588 Puerarin Puerarin metabolite M50 Hydrolysis - Hydrolysis Puerarin [2]
MR008594 Puerarin Puerarin-7-O-glucuronide Conjugation - Glucuronidation Puerarin [3]
References
1 Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine
2 Rapid profiling and identification of puerarin metabolites in rat urine and plasma after oral administration by UHPLC-LTQ-Orbitrap mass spectrometer
3 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes

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