Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008592)
Formula
SVG example
Hydroxylation
Reactant Puerarin Product Puerarin metabolite M21
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008598 Puerarin Daidzein-4',7'-di-O-sulfate Conjugation - Sulfation Puerarin [1]
MR008599 Puerarin Daidzein-4'-O-sulfate Conjugation - Sulfation Puerarin [1]
MR008595 Puerarin Puerarin metabolite M37 Unclear - Unclear Puerarin [2]
MR008596 Puerarin Puerarin metabolite M4 Unclear - Unclear Puerarin [2]
MR008588 Puerarin Puerarin metabolite M50 Hydrolysis - Hydrolysis Puerarin [2]
MR008597 Puerarin Puerarin-4'-O-glucuronide Conjugation - Glucuronidation Puerarin [1]
MR008594 Puerarin Puerarin-7-O-glucuronide Conjugation - Glucuronidation Puerarin [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007332 BRN-0064479 Genistein Unclear BRN-0064479 [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007347 Genistein 3'-hydroxygenistein Oxidation - 3'-hydroxylation BRN-0064479 [5]
MR007333 Genistein 6'-hydroxy-O-desmethylangolensin Unclear BRN-0064479 [4]
MR007340 Genistein Genistein-4'-glucuronide Unclear BRN-0064479 [5]
MR007345 Genistein Genistein-4'-sulfate Unclear BRN-0064479 [5]
MR007337 Genistein Genistein-7-glucuronide Unclear BRN-0064479 [5]
MR007343 Genistein Genistein-7-sulfate Unclear BRN-0064479 [5]
MR008593 Puerarin metabolite M21 Puerarin metabolite M55 Unclear - Unclear Puerarin [2]
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References
1 Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine
2 Rapid profiling and identification of puerarin metabolites in rat urine and plasma after oral administration by UHPLC-LTQ-Orbitrap mass spectrometer
3 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes
4 Comparative metabolism of genistin by human and rat gut microflora: detection and identification of the end-products of metabolism
5 Genistein: Dual Role in Women's Health

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