Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008723)
Formula
SVG example
Unclear
Reactant Normeperidine Product p-Aminophenylacetic acid
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008722 Anileridine Normeperidine Unclear - Unclear Anileridine [1]
MR013111 Meperidine Normeperidine Oxidation - N-demethylation Meperidine [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013113 Normeperidine N-hydroxynormeperidine Unclear - Unclear Meperidine [5]
MR013112 Normeperidine Normeperidinic acid Hydrolysis - Hydrolysis Meperidine [5]
MR013114 Normeperidine p-hydroxynormeperidine Unclear - Unclear Meperidine [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008726 Acetylanileridine p-Aminophenylacetic acid Unclear - Unclear Anileridine [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008724 P-Aminophenylacetic acid p-Acetylaminophenylacetic Acid Unclear - Unclear Anileridine [1]
References
1 N-dealkylation of anileridine to normeperidine
2 Meperidine and normeperidine levels following meperidine administration during labor. I. Mother
3 Effects of ethinyl estradiol on pharmacokinetics of meperidine and pentobarbital in the rat
4 Impact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine. Xenobiotica. 2020 Feb;50(2):209-222.
5 Urinary excretion of meperidine and its metabolites

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