Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013113)
Formula
SVG example
Unclear
Reactant Normeperidine Product N-hydroxynormeperidine
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008722 Anileridine Normeperidine Unclear - Unclear Anileridine [1]
MR013111 Meperidine Normeperidine Oxidation - N-demethylation Meperidine [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013112 Normeperidine Normeperidinic acid Hydrolysis - Hydrolysis Meperidine [5]
MR008723 Normeperidine p-Aminophenylacetic acid Unclear - Unclear Anileridine [1]
MR013114 Normeperidine p-hydroxynormeperidine Unclear - Unclear Meperidine [5]
References
1 N-dealkylation of anileridine to normeperidine
2 Meperidine and normeperidine levels following meperidine administration during labor. I. Mother
3 Effects of ethinyl estradiol on pharmacokinetics of meperidine and pentobarbital in the rat
4 Impact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine. Xenobiotica. 2020 Feb;50(2):209-222.
5 Urinary excretion of meperidine and its metabolites

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