Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013112)
Formula	Hydrolysis
	Reactant	Normeperidine	Product	Normeperidinic acid
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Hydrolysis - Hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR008722	Anileridine	Normeperidine	Unclear - Unclear	Anileridine	[1]
MR013111	Meperidine	Normeperidine	Oxidation - N-demethylation	Meperidine	[2], [3], [4]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013113	Normeperidine	N-hydroxynormeperidine	Unclear - Unclear	Meperidine	[5]
MR008723	Normeperidine	p-Aminophenylacetic acid	Unclear - Unclear	Anileridine	[1]
MR013114	Normeperidine	p-hydroxynormeperidine	Unclear - Unclear	Meperidine	[5]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013116	Meperidinic acid	Normeperidinic acid	Hydrolysis - Hydrolysis	Meperidine	[5]

References
1	N-dealkylation of anileridine to normeperidine
2	Meperidine and normeperidine levels following meperidine administration during labor. I. Mother
3	Effects of ethinyl estradiol on pharmacokinetics of meperidine and pentobarbital in the rat
4	Impact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine. Xenobiotica. 2020 Feb;50(2):209-222.
5	Urinary excretion of meperidine and its metabolites

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