Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009258)
Formula
SVG example
Unclear
Reactant Neupro Product N-desthienylethyl-rotigotine
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009255 Neupro N-despropyl-rotigotine Unclear - Unclear Neupro [1], [2]
MR009261 Neupro Neupro Metabolite M4 Unclear - Unclear Neupro [1]
MR009262 Neupro Neupro Metabolite M5 Unclear - Unclear Neupro [1], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010597 N-0923 N-0923 Metabolite M4 Unclear - Unclear N-0923 [4]
MR009597 Rotigotine N-desthienylethyl-rotigotine Unclear - Unclear Rotigotine [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010598 N-0923 Metabolite M4 N-0923 Metabolite M14 Unclear - Unclear N-0923 [4]
MR010600 N-0923 Metabolite M4 N-0923 Metabolite M5 Unclear - Unclear N-0923 [4]
MR010599 N-0923 Metabolite M4 N-0923 Metabolite M6c Unclear - Unclear N-0923 [4]
MR009599 N-desthienylethyl-rotigotine N-desthienylethyl-rotigotine Glucuronide Conjugation - Glucuronidation Rotigotine [1]
MR009598 N-desthienylethyl-rotigotine N-desthienylethyl-rotigotine Sulfate Oxidation - Sulfonation Rotigotine [1]
MR009259 N-desthienylethyl-rotigotine Neupro Metabolite M3 Unclear - Unclear Neupro [1]
MR009260 N-desthienylethyl-rotigotine Neupro Metabolite M6 Unclear - Unclear Neupro [1]
⏷ Show the Full List of MR
References
1 Absorption, disposition, metabolic fate, and elimination of the dopamine agonist rotigotine in man: administration by intravenous infusion or transdermal delivery
2 No influence of the CYP2C19-selective inhibitor omeprazole on the pharmacokinetics of the dopamine receptor agonist rotigotine
3 Identification of the human SULT enzymes involved in the metabolism of rotigotine. J Clin Pharmacol. 2016 Jun;56(6):754-60.
4 Determination of the dopamine D2 agonist N-0923 and its major metabolites in perfused rat livers by HPLC-UV-atmospheric pressure ionization mass spectrometry

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