Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009500)
Formula
CYP3A4 ...
SVG example
N-dealkylation
Reactant Ranolazine Product CVT-2534
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009508 Ranolazine CVT-2512 Conjugation - O-arylation Ranolazine [1]
MR009507 Ranolazine CVT-2513 Oxidation - N-dealkylation Ranolazine [1]
MR009502 Ranolazine CVT-2535 Oxidation - N-dealkylation Ranolazine [1]
MR009504 Ranolazine CVT-2551 Oxidation - Hydroxylation Ranolazine [1]
MR009506 Ranolazine CVT-2738 Oxidation - N-dealkylation Ranolazine [1], [2]
MR009509 Ranolazine CVT-3369 Hydrolysis - Hydrolysis Ranolazine [1]
MR009498 Ranolazine RS-88390 (CVT-2514) Oxidation - O-demethylation Ranolazine [1], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009501 CVT-2534 CVT-4786 Unclear - Unclear Ranolazine [1], [4]
References
1 Ranolazine for the treatment of chronic angina and potential use in other cardiovascular conditions
2 Comparison of pharmacokinetic parameters of ranolazine between diabetic and non-diabetic rats
3 Fatal, Intentional Overdose of Ranolazine: Post-Mortem Distribution of Parent Drug and its Major Metabolite
4 Development and validation of a sensitive LC-MS/MS assay for simultaneous quantitation of ranolazine and its three metabolites in human plasma

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