Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009502)
Formula
SVG example
N-dealkylation
Reactant Ranolazine Product CVT-2535
Reactant Info Product Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009508 Ranolazine CVT-2512 Conjugation - O-arylation Ranolazine [1]
MR009507 Ranolazine CVT-2513 Oxidation - N-dealkylation Ranolazine [1]
MR009500 Ranolazine CVT-2534 Oxidation - N-dealkylation Ranolazine [1]
MR009504 Ranolazine CVT-2551 Oxidation - Hydroxylation Ranolazine [1]
MR009506 Ranolazine CVT-2738 Oxidation - N-dealkylation Ranolazine [1], [2]
MR009509 Ranolazine CVT-3369 Hydrolysis - Hydrolysis Ranolazine [1]
MR009498 Ranolazine RS-88390 (CVT-2514) Oxidation - O-demethylation Ranolazine [1], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009503 CVT-2535 CVT-2537 Oxidation - Carboxylation Ranolazine [1]
References
1 Ranolazine for the treatment of chronic angina and potential use in other cardiovascular conditions
2 Comparison of pharmacokinetic parameters of ranolazine between diabetic and non-diabetic rats
3 Fatal, Intentional Overdose of Ranolazine: Post-Mortem Distribution of Parent Drug and its Major Metabolite

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