Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR009524)
Formula	UGT1A9 Glucuronidation
	Reactant	Regorafenib		Product	Regorafenib M7
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	UDP-glucuronosyltransferase 1A9 (UGT1A9)					DME Info
Metabolic Type	Conjugation - Glucuronidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR009514	Regorafenib	Regorafenib M2	Oxidation - N-oxidation	Regorafenib	[1], [2]
MR009519	Regorafenib	Regorafenib M3	Oxidation - Hydroxylation	Regorafenib	[2]

References
1	Quantification of cobimetinib, cabozantinib, dabrafenib, niraparib, olaparib, vemurafenib, regorafenib and its metabolite regorafenib M2 in human plasma by UPLC-MS/MS
2	Mass balance, metabolic disposition, and pharmacokinetics of a single oral dose of regorafenib in healthy human subjects

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