Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009544)
Formula
SVG example
N-demethylation
Reactant Riociguat Product Riociguat metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009548 Riociguat Riociguat metabolite M10 Oxidation - N-dealkylation Riociguat [1]
MR009546 Riociguat Riociguat metabolite M8 Hydrolysis - Hydrolysis Riociguat [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009545 Riociguat metabolite M1 Riociguat metabolite M4 Conjugation - N-glucuronidation Riociguat [2]
References
1 In vitroand in vivo investigation of metabolic fate of riociguat by HPLC-Q-TOF/MS/MS and in silico evaluation of the metabolites by ADMET predictor(?)
2 Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat

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