Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009548)
Formula Reactant Riociguat Product Riociguat metabolite M10
Reactant Info Product Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009544 Riociguat Riociguat metabolite M1 Oxidation - N-demethylation Riociguat [1], [2]
MR009546 Riociguat Riociguat metabolite M8 Hydrolysis - Hydrolysis Riociguat [3]
References
1 Population pharmacokinetics of riociguat and its metabolite in patients with chronic thromboembolic pulmonary hypertension from routine clinical practice
2 Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat
3 In vitroand in vivo investigation of metabolic fate of riociguat by HPLC-Q-TOF/MS/MS and in silico evaluation of the metabolites by ADMET predictor(?)

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.