Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009546)
Formula Reactant Riociguat Product Riociguat metabolite M8
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009544 Riociguat Riociguat metabolite M1 Oxidation - N-demethylation Riociguat [1], [2]
MR009548 Riociguat Riociguat metabolite M10 Oxidation - N-dealkylation Riociguat [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009547 Riociguat metabolite M8 Riociguat metabolite M9 Oxidation - N-demethylation Riociguat [3]
References
1 Population pharmacokinetics of riociguat and its metabolite in patients with chronic thromboembolic pulmonary hypertension from routine clinical practice
2 Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat
3 In vitroand in vivo investigation of metabolic fate of riociguat by HPLC-Q-TOF/MS/MS and in silico evaluation of the metabolites by ADMET predictor(?)

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