Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009837)
Formula	Unclear
	Reactant	Alpelisib	Product	Alpelisib Metabolite M4
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Unclear - Unclear

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR009840	Alpelisib	Alpelisib Metabolite M1	Multi-steps Reaction - Glucuronidation; oxidation	Alpelisib	[1]
MR009841	Alpelisib	Alpelisib Metabolite M12	Conjugation - N-Glucuronidation	Alpelisib	[1]
MR009842	Alpelisib	Alpelisib Metabolite M2	Oxidation - Oxidation	Alpelisib	[1]
MR009835	Alpelisib	Alpelisib Metabolite M3	Oxidation - Oxidation	Alpelisib	[1]
MR009843	Alpelisib	Alpelisib Metabolite M9	Oxidation - Oxidation	Alpelisib	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR009839	Alpelisib Metabolite M4	Alpelisib Metabolite M19	Unclear - Unclear	Alpelisib	[1]
MR009838	Alpelisib Metabolite M4	Alpelisib Metabolite M8	Oxidation - Oxidation	Alpelisib	[1]

References
1	Absorption, distribution, metabolism, and excretion of [(14)C]BYL719 (alpelisib) in healthy male volunteers. Cancer Chemother Pharmacol. 2015 Oct;76(4):751-60.

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