Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010579)
Formula Reactant 3-Hydroxyguanfacine Product Guanfacine Metabolite M2
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010578 Guanfacine 3-Hydroxyguanfacine Oxidation - Oxidation Guanfacine [1]
MR005062 Guanfacine hydrochloride 3-hydroxyguanfacine Oxidation - Oxidationn Guanfacine hydrochloride [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011444 3-hydroxyGuanfacine Glucuronide of hydroxy-Guanfacine Conjugation - Glucuronidation Guanfacine [1]
MR005064 3-hydroxyguanfacine Guanfacine 3-glucuronide Conjugation - O-glucuronidation Guanfacine hydrochloride [4]
MR005063 3-hydroxyguanfacine Guanfacine 3-sulfate Conjugation - Sulfation Guanfacine hydrochloride [4]
MR010580 3-Hydroxyguanfacine Guanfacine Metabolite M3 Conjugation - Sulfation Guanfacine [1]
MR011445 3-hydroxyGuanfacine Sulfate of hydroxy-Guanfacine Conjugation - Sulfation Guanfacine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010582 Guanfacine Metabolite M6 Guanfacine Metabolite M2 Conjugation - Glucuronidation Guanfacine [1]
References
1 Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended-release tablets
2 Determination of 3-hydroxy-guanfacine in biological fluids by electron-capture gas-liquid chromatography
3 Pharmacokinetics and metabolism of guanfacine in man: a review
4 DrugBank(Pharmacology-Metabolism):Guanfacine hydrochloride

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