Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011077)
Formula
SVG example
Unclear
Reactant Brimonidine Product Brimonidine metabolite M5
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011091 Brimonidine Benzimidazole derivative Unclear - Unclear Brimonidine [1]
MR011087 Brimonidine Brimonidine metabolite M1 Unclear - Unclear Brimonidine [2]
MR011083 Brimonidine Brimonidine metabolite M2 Oxidation - Oxidation Brimonidine [2]
MR011085 Brimonidine Brimonidine metabolite M3 Oxidation - Oxidation Brimonidine [2]
MR011088 Brimonidine Brimonidine metabolite M4 Unclear - Unclear Brimonidine [2]
MR011089 Brimonidine Dehydro-hydroxybrimonidine-M1 Oxidation - Hydroxylation Brimonidine [1]
MR011090 Brimonidine Dehydro-hydroxybrimonidine-M2 Oxidation - Hydroxylation Brimonidine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011082 Brimonidine metabolite M5 AGN 192076 Unclear - Unclear Brimonidine [2]
MR011078 Brimonidine metabolite M5 AGN 192119 Unclear - Unclear Brimonidine [2]
MR011081 Brimonidine metabolite M5 AGN 192614 Unclear - Unclear Brimonidine [2]
References
1 Characterization of benzimidazole and other oxidative and conjugative metabolites of brimonidine in vitro and in rats in vivo using on-line HID exchange LC-MS/MS and stable-isotope tracer techniques
2 Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase

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