Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011083)
Formula
SVG example
Oxidation
Reactant Brimonidine Product Brimonidine metabolite M2
Reactant Info Product Info
Metabolic Enzyme Aldehyde oxidase (AOX1) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011091 Brimonidine Benzimidazole derivative Unclear - Unclear Brimonidine [1]
MR011087 Brimonidine Brimonidine metabolite M1 Unclear - Unclear Brimonidine [2]
MR011085 Brimonidine Brimonidine metabolite M3 Oxidation - Oxidation Brimonidine [2]
MR011088 Brimonidine Brimonidine metabolite M4 Unclear - Unclear Brimonidine [2]
MR011077 Brimonidine Brimonidine metabolite M5 Unclear - Unclear Brimonidine [2]
MR011089 Brimonidine Dehydro-hydroxybrimonidine-M1 Oxidation - Hydroxylation Brimonidine [1]
MR011090 Brimonidine Dehydro-hydroxybrimonidine-M2 Oxidation - Hydroxylation Brimonidine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011084 Brimonidine metabolite M2 AGN 191858 Oxidation - Oxidation Brimonidine [2]
References
1 Characterization of benzimidazole and other oxidative and conjugative metabolites of brimonidine in vitro and in rats in vivo using on-line HID exchange LC-MS/MS and stable-isotope tracer techniques
2 Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase

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