Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011089)
Formula
SVG example
Hydroxylation
Reactant Brimonidine Product Dehydro-hydroxybrimonidine-M1
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011091 Brimonidine Benzimidazole derivative Unclear - Unclear Brimonidine [1]
MR011087 Brimonidine Brimonidine metabolite M1 Unclear - Unclear Brimonidine [2]
MR011083 Brimonidine Brimonidine metabolite M2 Oxidation - Oxidation Brimonidine [2]
MR011085 Brimonidine Brimonidine metabolite M3 Oxidation - Oxidation Brimonidine [2]
MR011088 Brimonidine Brimonidine metabolite M4 Unclear - Unclear Brimonidine [2]
MR011077 Brimonidine Brimonidine metabolite M5 Unclear - Unclear Brimonidine [2]
MR011090 Brimonidine Dehydro-hydroxybrimonidine-M2 Oxidation - Hydroxylation Brimonidine [1]
References
1 Characterization of benzimidazole and other oxidative and conjugative metabolites of brimonidine in vitro and in rats in vivo using on-line HID exchange LC-MS/MS and stable-isotope tracer techniques
2 Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase

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