Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011206)
Formula
SVG example
N-demethylation; O-demethylation
Reactant Norhydrocodone Product Hydrocodone M272
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - N-demethylation; O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011205 Hydrocodone Norhydrocodone Oxidation - N-demethylation Hydrocodone [1]
MR005123 Hydrocodone bitartrate Norhydrocodone Oxidation - N-demethylation Hydrocodone bitartrate [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011217 Norhydrocodone Norhydrocodol Reduction - Ketone reduction Hydrocodone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011210 Hydrocodone Hydrocodone M272 Multi-steps Reaction - N-demethylation; O-demethylation Hydrocodone [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014001 Hydrocodone M272 Hydrocodone M274 Oxidation - N-demethylation Hydrocodone [1]
MR011216 Hydrocodone M272 Hydrocodone M488 Conjugation - Glucuronidation Hydrocodone [1]
MR011207 Hydrocodone M272 Hydrocodone M274 Oxidation - N-demethylation Hydrocodone [1]
References
1 Update on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite
2 CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. Br J Clin Pharmacol. 2004 Mar;57(3):287-97.

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