Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011489)
Formula
SVG example
N-dealkylation
Reactant S-297995 Product Nor-naldemedine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A (CYP3A) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011491 S-297995 Benzamidine Multi-steps Reaction - Reduction; Hydrolysis S-297995 [1]
MR011493 S-297995 Naidemedine-(7R)-7-hydroxide Oxidation - Oxidation S-297995 [1]
MR011494 S-297995 Naidemedine-(7S)-7-hydroxide Oxidation - Oxidation S-297995 [1]
MR011495 S-297995 Naidemedine-3-G Conjugation - Glucuronide conjugation S-297995 [1]
MR011485 S-297995 Naldemedine carboxylic acid Hydrolysis - Hydrolysis S-297995 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011490 Nor-naldemedine MS416 Multi-steps Reaction - Reduction; Hydrolysis S-297995 [1]
References
1 Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects

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