Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011491)
Formula
SVG example
Reduction; Hydrolysis
Reactant S-297995 Product Benzamidine
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Reduction; Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011493 S-297995 Naidemedine-(7R)-7-hydroxide Oxidation - Oxidation S-297995 [1]
MR011494 S-297995 Naidemedine-(7S)-7-hydroxide Oxidation - Oxidation S-297995 [1]
MR011495 S-297995 Naidemedine-3-G Conjugation - Glucuronide conjugation S-297995 [1]
MR011485 S-297995 Naldemedine carboxylic acid Hydrolysis - Hydrolysis S-297995 [1]
MR011489 S-297995 Nor-naldemedine Oxidation - N-dealkylation S-297995 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011492 Benzamidine MS179 Multi-steps Reaction - Oxidation,Glycine conjugation S-297995 [1]
References
1 Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects

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