Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012308)
Formula
SVG example
Oxidation; Dioxine oxidation ring opening
Reactant LIK-066 Product LIK-066 M12,15
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Oxidation; Dioxine oxidation ring opening
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012306 LIK-066 LIK-066 M13,14 Oxidation - Oxidation LIK-066 [1]
MR012315 LIK-066 LIK-066 M17,27 Multi-steps Reaction - Oxidation; direct glucuronidation LIK-066 [1]
MR012311 LIK-066 LIK-066 M20,M21 Multi-steps Reaction - Oxidation; Dioxine oxidation ring opening LIK-066 [1]
MR012303 LIK-066 LIK-066 M22 Oxidation - Oxidation LIK-066 [1]
MR012314 LIK-066 LIK-066 M28 Multi-steps Reaction - Oxidation; Desaturation LIK-066 [1]
MR012313 LIK-066 LIK-066 M7 Multi-steps Reaction - O-dealkylation; Dioxine oxidation ring opening; glucurondation LIK-066 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012310 LIK-066 M12,15 LIK-066 M1,2,3,5 Unclear - Unclear LIK-066 [1]
MR012309 LIK-066 M12,15 LIK-066 M11 Conjugation - Glucuronidation LIK-066 [1]
References
1 Pharmacokinetics, metabolism, and excretion of licogliflozin, a dual inhibitor of SGLT1/2, in rats, dogs, and humans

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