Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012315)
Formula Reactant LIK-066 Product LIK-066 M17,27
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Multi-steps Reaction - Oxidation; direct glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012308 LIK-066 LIK-066 M12,15 Multi-steps Reaction - Oxidation; Dioxine oxidation ring opening LIK-066 [1]
MR012306 LIK-066 LIK-066 M13,14 Oxidation - Oxidation LIK-066 [1]
MR012311 LIK-066 LIK-066 M20,M21 Multi-steps Reaction - Oxidation; Dioxine oxidation ring opening LIK-066 [1]
MR012303 LIK-066 LIK-066 M22 Oxidation - Oxidation LIK-066 [1]
MR012314 LIK-066 LIK-066 M28 Multi-steps Reaction - Oxidation; Desaturation LIK-066 [1]
MR012313 LIK-066 LIK-066 M7 Multi-steps Reaction - O-dealkylation; Dioxine oxidation ring opening; glucurondation LIK-066 [1]
References
1 Pharmacokinetics, metabolism, and excretion of licogliflozin, a dual inhibitor of SGLT1/2, in rats, dogs, and humans

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