Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012429)
Formula	O-despiperidine
	Reactant	AZD8931	Product	AZD8931 M18
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Oxidation - O-despiperidine

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR012436	AZD8931	AZD8931 M10	Other reaction - Hydroxy-chlorofluorophenylation	AZD8931	[1]
MR012434	AZD8931	AZD8931 M11	Oxidation - Monooxygenation	AZD8931	[1]
MR012427	AZD8931	AZD8931 M12	Oxidation - O-desmethylation	AZD8931	[1]
MR012442	AZD8931	AZD8931 M13	Oxidation - N-desmethylation	AZD8931	[1]
MR012439	AZD8931	AZD8931 M14	Conjugation - N-hydroxymethylation	AZD8931	[1]
MR012441	AZD8931	AZD8931 M15	Other reaction - Hydroxypiperidine	AZD8931	[1]
MR012443	AZD8931	AZD8931 M20	Unclear - N-acetic acid	AZD8931	[1]
MR012432	AZD8931	AZD8931 M9	Oxidation - N-dealkylation	AZD8931	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR012431	AZD8931 M18	AZD8931 M1	Conjugation - O-despiperidinyl glucosidation	AZD8931	[1]
MR012430	AZD8931 M18	AZD8931 M5	Conjugation - O-despiperidinyl sulfation	AZD8931	[1]

References
1	Metabolic disposition of AZD8931, an oral equipotent inhibitor of EGFR, HER2 and HER3 signalling, in rat, dog and man

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