Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013209)
Formula Reactant Remdesivir Product Remdesivir carboxylate
Reactant Info Product Info
Metabolic Type Hydrolysis - Ester hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013220 Remdesivir GS-441524 Unclear Remdesivir [1]
MR013215 Remdesivir Remdesivir Alanine Metabolite (Ala-Met; GS-704277) Unclear Remdesivir [2]
MR013218 Remdesivir Remdesivir M1 Unclear Remdesivir [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013210 Remdesivir carboxylate Remdesivir cyclic anhydride Other reaction - Cyclization Remdesivir [3]
References
1 Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19
2 Viral target and metabolism-based rationale for combined use of recently authorized small molecule COVID-19 medicines: Molnupiravir, nirmatrelvir, and remdesivir
3 Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.