Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013218)
Formula
CYP3A4 ...
SVG example
Reactant Remdesivir Product Remdesivir M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013220 Remdesivir GS-441524 Unclear Remdesivir [1]
MR013215 Remdesivir Remdesivir Alanine Metabolite (Ala-Met; GS-704277) Unclear Remdesivir [2]
MR013209 Remdesivir Remdesivir carboxylate Hydrolysis - Ester hydrolysis Remdesivir [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013219 Remdesivir M1 Remdesivir Nucleoside Monophosphate Unclear Remdesivir [2]
References
1 Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19
2 Viral target and metabolism-based rationale for combined use of recently authorized small molecule COVID-19 medicines: Molnupiravir, nirmatrelvir, and remdesivir
3 Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

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