Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013220)
Formula
	Reactant	Remdesivir	Product	GS-441524
	Reactant	Reactant Info	Product	Product Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013215	Remdesivir	Remdesivir Alanine Metabolite (Ala-Met; GS-704277)	Unclear	Remdesivir	[1]
MR013209	Remdesivir	Remdesivir carboxylate	Hydrolysis - Ester hydrolysis	Remdesivir	[2]
MR013218	Remdesivir	Remdesivir M1	Unclear	Remdesivir	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR014046	Remdesivir Nucleoside Monophosphate	GS-441524	Unclear	Remdesivir	[3]
MR013214	Remdesivir Nucleoside Monophosphate	GS-441524	Unclear	Remdesivir	[2]

References
1	Viral target and metabolism-based rationale for combined use of recently authorized small molecule COVID-19 medicines: Molnupiravir, nirmatrelvir, and remdesivir
2	Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
3	Population pharmacokinetic modeling of GS-441524, the active metabolite of remdesivir, in Japanese COVID-19 patients with renal dysfunction

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