Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013331)
Formula
CES1 ...
SVG example
Deacetylation
Reactant 6-Monoacetylmorphine Product Morphine
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Carboxylesterase 2 (CES2) DME Info
Metabolic Type Oxidation - Deacetylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013330 Heroin 6-Monoacetylmorphine Oxidation - Deacetylation Heroin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004096 Codeine Morphine Conjugation - Glucuronidation Codeine [2], [3], [4]
MR012868 Ethylmorphine Morphine Oxidation - N-dealkylation Ethylmorphine [5], [6], [7], [8]
References
1 Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases
2 Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity
3 Pharmacokinetics and metabolism of codeine in humans
4 Pharmacogenetics of analgesic drugs
5 Ethylmorphine metabolism in isolated rat hepatocytes
6 Urinary excretion of codeine, ethylmorphine, and their metabolites: relation to the CYP2D6 activity
7 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
8 Metabolism and pharmacokinetics of morphine in neonates: A review

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