Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012868)
Formula	N-dealkylation
	Reactant	Ethylmorphine	Product	Morphine
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Oxidation - N-dealkylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR012878	Ethylmorphine	Ethylmorphine-6-glucuronide	Unclear	Ethylmorphine	[1]
MR012872	Ethylmorphine	Norethylmorphine	Unclear	Ethylmorphine	[2]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR004096	Codeine	Morphine	Conjugation - Glucuronidation	Codeine	[3], [4], [5]
MR013331	6-Monoacetylmorphine	Morphine	Oxidation - Deacetylation	Heroin	[6]

References
1	Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose. Br J Clin Pharmacol. 1995 Jun;39(6):611-20.
2	Ethylmorphine metabolism in isolated rat hepatocytes
3	Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity
4	Pharmacokinetics and metabolism of codeine in humans
5	Pharmacogenetics of analgesic drugs
6	Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases

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