Details of the Metabolic Reaction (MR)
| General Information of This Metabolic Reaction (MR) (ID: MR013532) | ||||||
|---|---|---|---|---|---|---|
| Formula | ||||||
| Reactant | Sotorasib Metabolite M12 | Product | Sotorasib Metabolite M30 | |||
| Reactant Info | Product Info | |||||
| Metabolic Enzyme | Gamma-glutamyltranspeptidase 5 (GGT5) | DME Info | ||||
| Cytosol aminopeptidase (LAP3) | DME Info | |||||
| Metabolic Type | Hydrolysis - Hydrolysis | |||||
| Other MR(s) Related to The Reactant of This MR | |||||||||||||||||||||||||||||
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| Other MR(s) That Produce The Reactant of This MR | |||||||||||||||||||||||||||||
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| Other MR(s) Related to The Product of This MR | |||||||||||||||||||||||||||||||||||
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| Other MR(s) That Metabolize The Produtc of This MR | |||||||||||||||||||||||||||||||||||
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| References | ||||||
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| 1 | Absorption, Distribution, Metabolism, and Excretion of [(14)C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism | |||||
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