Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013533)
Formula
SVG example
Hydrolysis
Reactant Sotorasib Metabolite M30 Product Sotorasib Metabolite M10
Reactant Info Product Info
Metabolic Enzyme Bleomycin hydrolase (BLMH) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013532 Sotorasib Metabolite M12 Sotorasib Metabolite M30 Hydrolysis - Hydrolysis Sotorasib [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013538 Sotorasib Metabolite M30 Sotorasib Metabolite M61 Unclear Sotorasib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013537 Sotorasib Metabolite M10 Sotorasib Metabolite M20 Unclear Sotorasib [1]
MR013534 Sotorasib Metabolite M10 Sotorasib Metabolite M55 Oxidation - Oxidation Sotorasib [1]
References
1 Absorption, Distribution, Metabolism, and Excretion of [(14)C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism
2 Absorption, metabolism and excretion of [(14)C]-sotorasib in healthy male subjects: characterization of metabolites and a minor albumin-sotorasib conjugate

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