Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013702)
Formula
UGT1A1 ...
SVG example
Glucuronidation
Reactant Opicapone Product BIA 9-1106
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013696 Opicapone BIA 9-1079 Reduction - Reduction Opicapone [1]
MR013706 Opicapone BIA 9-1100 Oxidation - Methylation Opicapone [1]
MR013707 Opicapone BIA 9-1101 Multi-steps Reaction - Methylation; reduction Opicapone [1]
MR013704 Opicapone BIA 9-1103 Conjugation - Sulfation Opicapone [1]
MR013705 Opicapone BIA 9-1104 Oxidation - Methylation Opicapone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013703 BIA 9-1106 BIA 9-1101 Unclear Opicapone [2]
References
1 Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor, in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor
2 Metabolism and disposition of opicapone in the rat and metabolic enzymes phenotyping

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