Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR014071)
Formula Reactant Lumateperone tosylate Product IC200161
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010268 Lumateperone tosylate IC200565 Oxidation - N-desmethylation lumateperone tosylate [1]
MR010266 Lumateperone tosylate ICI200131 Unclear - Unclear lumateperone tosylate [1]
MR014073 Lumateperone tosylate ICI200131 Reduction - Reduction lumateperone tosylate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011408 ITI-007 IC200161 Oxidation - Dealkylation ITI-007 [1]
References
1 An evaluation of lumateperone tosylate for the treatment of schizophrenia
2 Dopamine D(2) receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia

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