Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR014073)
Formula Reactant Lumateperone tosylate Product ICI200131
Reactant Info Product Info
Metabolic Enzyme Aldo-keto reductases (AKR) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014071 Lumateperone tosylate IC200161 Oxidation - Dealkylation lumateperone tosylate [1]
MR010268 Lumateperone tosylate IC200565 Oxidation - N-desmethylation lumateperone tosylate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011407 ITI-007 ICI200131 Reduction - Reduction ITI-007 [2]
References
1 Dopamine D(2) receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia
2 An evaluation of lumateperone tosylate for the treatment of schizophrenia

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