Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00029)
Xenobiotics Name
Valproic acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
3121
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Tartrate-resistant acid ATPase (ACP5) DME Info Homo sapiens [1]
Acetyl-CoA synthetase (ACSS2) DME Info Homo sapiens [1]
Adenosine aminohydrolase (ADA) DME Info Homo sapiens [2]
Alcohol dehydrogenase class-I alpha (ADH1A) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-I gamma (ADH1C) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-II (ADH4) DME Info Homo sapiens [1]
Alcohol dehydrogenase class-V (ADH6) DME Info Homo sapiens [2]
Aldo-keto reductase 1D1 (AKR1D1) DME Info Homo sapiens [3]
Succinate-semialdehyde dehydrogenase (ALDH5A1) DME Info Homo sapiens [1]
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [4]
Arylsulfatase B (ARSB) DME Info Homo sapiens [5]
Asparagine synthetase (ASNS) DME Info Homo sapiens [1]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [2]
Choline dehydrogenase (CHDH) DME Info Homo sapiens [6]
Catechol O-methyltransferase (COMT) DME Info Homo sapiens [7]
Cholesterol desmolase (CYP11A1) DME Info Homo sapiens [8]
Aromatase (CYP19A1) DME Info Homo sapiens [9]
Steroid 21-hydroxylase (CYP21A2) DME Info Homo sapiens [10]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [1]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [11]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [12]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [13]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [13]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [14]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [15]
Leukotriene B4 omega-hydroxylase (CYP4F3) DME Info Homo sapiens [10]
Deoxycytidylate deaminase (DCTD) DME Info Homo sapiens [1]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [16], [17]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [18], [19]
Thymidylate kinase (DTYMK) DME Info Homo sapiens [19]
Bifunctional epoxide hydrolase 2 (EPHX2) DME Info Homo sapiens [18], [19]
Oleamide hydrolase 1 (FAAH) DME Info Homo sapiens [1]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [1]
Dimethylaniline oxidase 1 (FMO1) DME Info Homo sapiens [2]
Galactose kinase (GALK1) DME Info Homo sapiens [18], [19]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [1]
Glutamine amidotransferase (GMPS) DME Info Homo sapiens [1]
Glutathione S-transferase omega-1 (GSTO1) DME Info Homo sapiens [20]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [1]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [1]
Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME Info Homo sapiens [19]
Beta-HSD adrenal and gonadal type (HSD3B2) DME Info Homo sapiens [1]
Methionine adenosyltransferase II beta (MAT2B) DME Info Homo sapiens [1]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [17], [21]
Peptide methionine sulfoxide reductase (MSRA) DME Info Homo sapiens [1]
Methionine-R-sulfoxide reductase B2 (MSRB2) DME Info Homo sapiens [1]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [1]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [1]
Phosphodiesterase 5A (PDE5A) DME Info Homo sapiens [1]
Phosphoribosylformylglycinamidine synthase (PFAS) DME Info Homo sapiens [1]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [1]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [22], [2]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [22]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info Homo sapiens [23]
UDP-glucuronosyltransferase 2A3 (UGT2A3) DME Info Homo sapiens [24], [25]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info Homo sapiens [26]
Uridine 5'-monophosphate synthase (UMPS) DME Info Homo sapiens [1]
Tryptophanyl-tRNA synthetase mitochondrial (WARS2) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [1]
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [1]
Retinal dehydrogenase 2 (ALDH1A2) DME Info Homo sapiens [1]
Aldehyde dehydrogenase 2 (ALDH2) DME Info Homo sapiens [27]
Alkaline phosphatase (ALPL) DME Info Homo sapiens [28]
Bleomycin hydrolase (BLMH) DME Info Homo sapiens [28]
Carbonic anhydrase II (CA2) DME Info Homo sapiens [18]
NADPH-dependent carbonyl reductase 3 (CBR3) DME Info Homo sapiens [2]
Serine sulfhydrase (CBS) DME Info Homo sapiens [18]
Cytidine aminohydrolase (CDA) DME Info Homo sapiens [28]
Carboxylesterase 1 (CES1) DME Info Homo sapiens [22], [2]
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [16]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [29]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [13]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [9]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [13]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [30]
Glutamine synthetase (GLUL) DME Info Homo sapiens [31]
Glutathione S-transferase omega-2 (GSTO2) DME Info Homo sapiens [32]
Beta-glucuronidase (GUSB) DME Info Homo sapiens [5]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [18], [19]
Iduronate 2-sulfatase (IDS) DME Info Homo sapiens [33]
Monoamine oxidase type A (MAO-A) DME Info Homo sapiens [34]
Monoamine oxidase type B (MAO-B) DME Info Homo sapiens [35]
Microsomal glutathione S-transferase 2 (MGST2) DME Info Homo sapiens [36]
Neprilysin (MME) DME Info Homo sapiens [1]
Metallothionein-1A (MT1A) DME Info Homo sapiens [37]
Metallothionein-2A (MT2A) DME Info Homo sapiens [37]
Methylenetetrahydrofolate reductase (MTHFR) DME Info Homo sapiens [38], [39]
N-acetyltransferase 2 (NAT2) DME Info Homo sapiens [2]
NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2) DME Info Homo sapiens [1]
Purine nucleoside phosphorylase (PNP) DME Info Homo sapiens [40]
Pyridoxamine-phosphate oxidase (PNPO) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [36]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [1]
Sulfotransferase 1C4 (SULT1C4) DME Info Homo sapiens [32]
Transglutaminase H (TGM2) DME Info Homo sapiens [1]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [9]
Xanthine dehydrogenase/oxidase (XDH) DME Info Homo sapiens [22]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info Ki = 1600 microM [26]
References
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21 A comparative transcriptomic study on the effects of valproic acid on two different hESCs lines in a neural teratogenicity test system. Toxicol Lett. 2014 Nov 18;231(1):38-44.
22 Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides. J Biol Chem. 2018 Apr 13;293(15):5600-5612.
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